Creative Piece 1

Creative Piece 1

Published on 1 April 2022
Transcript
00:00
Do you know someone who has diabetes or dementia,
00:01
Blood Glucose Level
00:03
or even both?
00:05
As the world's older population grows in size,
00:08
the proportion of people affected by ageing-related diseases 
00:11
also increases.
00:12
Diabetes,
00:12
Diabetes
00:13
Type 2
00:14
specifically Type 2 diabetes, 
00:15
Diabetes
00:15
Type 2
00:15
90%
00:16
which makes up 90 percent of diabetes cases, 
00:19
is one of the most common ageing-related diseases
00:22
and affects about 1 in 11 adults worldwide.
00:26
Type 2 diabetes is usually diagnosed as excess glucose in blood
00:26
Blood Glucose >11.1 mmol
00:30
and diabetic patients can experience symptoms such as
00:31
Symptoms of Type 2 Diabetes
00:33
tiredness, increased urination, and excessive thirst.
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WC
00:37
Type 2 diabetes is caused by insulin resistance
00:40
Insulin Resistance
00:41
in which the body tissues become less sensitive to the effects of insulin hormone
00:41
body tissues become less sensitive to the effects of insulin hormone
00:45
and production of insulin is reduced.
00:48
Pancreas
00:48
Blood glucose level 
00:48
Blood vessel
00:48
Glucose molecules
00:48
During and after meals, 
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pancreatic beta cells detect an increase in blood glucose level
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Glucose
00:51
Pancreatic beta cell
00:54
Insulin
00:54
Blood vessel
00:54
and secretes insulin into the bloodstream.
00:56
Insulin stimulates the uptake of glucose by body tissues to be used for energy,
00:59
Muscle
00:59
Liver
00:59
Adipose tissue
01:01
and uptake of glucose by liver to be stored for future use.
01:05
Insulin resistance happens when the body tissues become less sensitive
01:05
Glucose
01:05
Glucose transporter
01:05
Insulin
01:05
Insulin receptor
01:05
Mitochondria - "energy centre"
01:05
Normal insulin signalling
01:05
Normal insulin sensitivity
01:09
to the stimulation of insulin, and the uptake of glucose decreases,
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Decreased insulin sensitivity
01:10
Impaired insulin signalling
01:13
causing excess glucose to remain in the blood.
01:16
Blood glucose > 11.1 mmol/L
01:17
If left untreated, Type 2 diabetes can result in serious complications,
01:22
such as inflammation that can lead to nerve damage in the feet and legs, 
01:26
which can result in wounds that heal very slowly,
01:29
and increases the chances of infection and amputation.
01:33
Excess glucose in blood can also damage the blood vessels in the retina,
01:38
causing blood and fluid to leak into the retina
01:41
In severe cases, new blood vessels can form in the eye
01:45
and they rupture easily,
01:47
which can lead to vision problems and vision loss.