-> 10-30 mg every 4 hours or as directed by physician
-> Oral dose must be larger than injection or IV dose because Morphine,
along with all other opioids, undergo the first-pass effect allowing
less to be absorbed by the body
-> Dosage is a patient dependent variable, therefore the doctor will
the correct dosage for each patient
-> No maximum dosage for morphine, because patients can develop
tolerance, so the more and longer patients take it the dosages may
need to be increased
00:33
Pharmacokinetics:
00:33
-> When taken orally, the patient will start to notice pain relief in 30-60
minutes based on their tolerance
-> Morphine is metabolized in the liver
-> Morphine stays in the body for approximately 4-6 hours and then is
excreted through the urine and plasma
Antidote: Narcan
00:54
Pharmacodynamics:
00:54
-> The Central Nervous System (CNS) is the most affected/ primary site
of action by morphine in the body
-> Absorbed in the GI tract
-> Can potentially accumulate in many of the body's organs including:
lungs, liver, kidney, spleen
01:06
-> Helps to relieve moderate to sever pain
-> Before and during invasive diagnostic procedures
-> Treatment of GI disorders
-> Treatment of severe, unproductive cough
-> Treatment of acute pulmonary edema
01:06
Use of Morphine:
01:20
Therapeutic Effects:
01:20
-> Analgesia-pain relief
-> Reduction in GI pain
-> Reduction in coughing
01:25
-> CNS Depression
-> Sedation, drowsiness, sleep, decreased mental/ physical activity, N/ V
-> Decrease RR and BP
-> Constipation, urinary retention, itching
01:25
Adverse Effects:
01:38
Patient Education:
01:39
->Do not crush time-release medication
-> Wake up if you are taking Morphine continually to maintain
scheduled dosage
-> Have Narcan available for respiratory depression
01:50
Questions:
01:50
1. What do you give the patient if they are taking Morphine and their
RR drops to 5?
2. What is the maximum dosage for Morphine?
Sources:
https://www.rxlist.com/roxanol-drug.htm#indications
https://pubmed.ncbi.nlm.nih.gov/8491060/
By: Jayson Hall
