The History of Aspirin

The History of Aspirin

Published on 12 April 2021
VB
Veronica Blánquez Benítez
Veronica's Personal Gallery
Transcript
00:00
The History of Aspirin
00:01
Man has always tried to find a remedy to alleviate his pain. In ancient times, he found it in nature itself.
00:09
Research and modifications of willow bark led to the active principle of this plant, which scientists called salicin, which is used to synthesize salicylic acid, which gives rise to acetylsalicylic acid.
00:15
Its traditional indications are: Headache Dental pain Spasms, menstrual cramps Edemas Rheumatism Muscle joint discomfort Fever Cold or flu discomfort It also protects against the risk of carido and cerebrovascular diseases.
00:16
Benefits of Aspirin
00:17
It is an anti-inflammatory, analgesic, antipyretic, antirheumatic and vascular protector.
00:23
Synthesis of Aspirin
00:25
White willow bark had therapeutic qualities such as calming fever and relieving pain. Over time, natural remedies gave way to scientific research and chemical solutions.
00:31
Contraindications to be taken into account when administering acetylsalicylic acid:
00:32
Hypersensitivity to salicylatesAsthmaGastroduodenal ulcerCoagulation disordersHistory of nephropathyPregnancy during the last trimester
00:38
In 1897 Felix Hoffman, a chemist of the Bayer company, succeeded in obtaining in a pure and stable form the acetylsalicylic acid marketed under the name Aspirin.
00:45
To prevent a possible shortage of salicin in the future, the need was created to find the chemical formula that would synthesize this substance from willow bark.
00:52
Mechanism of action of Aspirin
00:53
The biological mechanisms of inflammation...pain or fever are very similar, substances known as prostaglandins are generated in the area of infection, they are the messengers of pain. These substances inform the central nervous system of the aggression and the biological reaction of inflammation and fever is set in motion. Therefore, Aspirin interrupts these mechanisms by inhibiting the production of protaglandins, so there is no transmission of the painful sensation. Thus, thanks to this action, the normal temperature of the organism is restored, the tissues are deflated and the pain is relieved.